Gaps between the genes
The spaces between the genes have proved to be important in explaining the vast differences found between apes and humans. Rather surprisingly, non-coding sequences of DNA make up more than 90 percent of the human genome. Reciently, scientists have discovered that they contain elements than can control how and when nearby genes are activated.
An international team led by genome researcher Edward Rubin of the Lawrence Berkeley National Laboratory in California wonders if these non-coding regions play a role in human evolution. They looked at more than 100,000 samples of non-coding DNA sequences that seem have been conserved during evolution. Statistical tests proved that almost one thousand sequences were not due to simple chance, suggesting that they were caused by natural selection.
The strongest evidence was found in sequences next to genes involved in helping the neurons to keep together. These sequences may have contributed to the evolution of uniquely human cognitive talents. Rubin says that neuronal adhesion molecules play an important role in “wiring” the brain. The formation of connective synapses between nerve cells is involved in these processes, which are crucial in early brain development, as also in adult learning, memory, and cognition.
A molecular biologist at the University of California, Ajit Varki, says that the conclusions sound interesting and plausible, but cautions that the findings should be considered tentative because the gene databases that were used give only a broad generalization about a gene’s function.
Science, 3 November 2006